Inflammatory breast cancer: a race against screening

Inflammatory breast cancer [IBC] is a rare and aggressive form of breast cancer that is characterized by rapid progression, younger age of onset, and poor prognosis. These findings underline a long list of differential diagnosis where clinical, radiological and histological inputs are essential. One limitation to establishing the diagnosis is a poor sensitivity of a test with high negative predictive value. In this paper, we report the case of a rapid growing IBC where two imaging techniques failed at establishing the diagnosis

two-front war: targeting synchronous metastatic pancreatic and renal cell carcinomas with the combination of gemcitabine and sunitinib

The occurrence of multiple synchronous primary tumors is extremely rare. The management plan of synchronous cancers has long been debatable and difficult mainly in tumors with different molecular characteristics. In this report, we present the second case in literature of a concomitant diagnosis of a metastatic pancreatic adenocarcinoma and a locally advanced renal cell carcinoma. We also elaborate on our management combining chemo-therapy and targeted therapy through an extensive review of literature

Epidemiology and survival analysis of gastrointestinal stromal tumors in lebanon: real-life study from a hospital tumor registry 2000-2015

Background: We report, to our knowledge, one of the largest studies concerning gastrointestinal stromal tumors [GIST] in the Middle East. We also present a survival analysis of GIST in our 15-year real-life experience

Methods: We studied demographic, epidemiologic and survival characteristics of 70 patients with confirmed GIST in a cross-sectional study between 2000 and 2015

Results: The .median age of our patients was 62 +/-12.8 years [range, 25-84] with a male to female ratio of 1.7. The gastric and the small intestine GIST were the most frequent primary sites. The majority of our patients had localized disease at diagnosis [81.4%]. Metastasis m limited to the abdominal cavity and lymph node spreadinc occurred in 14.3%. After a median follow up of 838 dap [range 48-4309 days] with only two patients reporte dead, two and five-year overall survival rates were 98% and 95% respectively. Median overall survival was not reached

Conclusion: In the light of our results, molecular profili of Lebanese patients with GIST would be of interest t detect the particularities responsible for the increase! overall survival and lymph node spreading